With the continuous emergence and aggravation of bacterial resistance, it is necessary to develop new efficient and rapid sterilization methods for clinical medical problems such as drug-resistant bacterial infections and bacterial membranes that are difficult to treat with traditional antibiotics. Recently, Associate Professor Li Jiebo, Assoc Fast and efficient removal of membranes.

Figure 1 Schematic diagram of the sterilization mechanism of MXene combined with light.

Figure 2 The combination of MXene and light can quickly and efficiently kill bacteria and bacterial membranes.

In order to test the broad-spectrum antibacterial properties of the program, the authors conducted rapid sterilization experiments on a variety of drug-resistant bacteria including drug-resistant methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE). . It was found that the combination of MXene and 808 nm laser of titanium dicarbide type showed significant antibacterial properties to the 15 kinds of bacteria tested. In addition, this sterilization program can kill deep-seated bacteria by destroying the bacterial membrane structure, and quickly remove the bacterial membrane formed by MRSA. In addition, research on the antibacterial mechanism shows that MXene and near-infrared lasers mainly kill bacteria through physical MXene insertion and contact and photothermal effects, which can significantly reduce the generation of bacterial resistance.

This work proposes a plan to physically remove a variety of drug-resistant bacteria and bacterial membranes, and expands the potential application range of the new two-dimensional material MXene in the field of biomedicine and clinical.

The research results were recently published in Science China Materials, 2020, 10.1007/s40843-020-1451-7.
Article source: China Science-Materials
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