Human choroidal melanoma (HCM) is one of the most common primary intraocular tumors and is prone to liver metastasis due to the lack of sensitive non-invasive treatment. For the imaging diagnosis and treatment of choroidal melanoma,

Jinhai Huang, Mei Yang, A-Yong Yu et al designed A micro-environment-triggered degradable hydrogel (RenP-ICG@pNIPAM: DOx-FA) based on ultra-small (<5 nm) rare earth nanoparticles (RENPs) with enhanced NIR-II luminescence.

Main points of this article:

1) Ultra-small diameter can significantly improve the NIR-II luminescence performance of RENPs. RENPs was encapsulated by a dual-response PNIPAM hydrogel, which released the drug in response to thermal energy and glutathione in a tumor microenvironment.

3) In addition, the biodegradability of hydrogel composites under physiological conditions is conducive to improving the effect of photothermal chemotherapy and reducing long-term biotoxicity.

In summary, hydrogels with enhanced NIR-II imaging and microenvironment-triggered metabolism may provide a promising strategy for sensitive and non-invasive imaging and phototherapy of ocular tumors.

reference

Luoyuan Li, et al. Microenvironment-Triggered Degradable Hydrogel for Imaging Diagnosis and Combined Treatment of Intraocular Choroidal Melanoma. ACS Nano, 2020.

2) The effects of different treatment conditions on in vivo and in vitro nIR-II imaging detection and anti-tumor activity of ocular choroidal melanoma-1 cells and tumor-bearing mice were systematically compared.

DOI: 10.1021 / acsnano. 0 c06000

https://doi.org/10.1021/acsnano.0c06000

Source: Theory of Oddities

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