Tumor fibrotic stroma will have complex negative effects on the therapeutic effect of nanomedicine. Although studies have shown that nanoparticle carriers have a good effect in overcoming biological barriers to drug delivery, fibrosis can still lead to hypoxia, immunosuppression, and limited immune cell infiltration, thereby reducing the anti-tumor effect of nanosystems. Associate Professors Lin Hou and Lu Siyu of Zhengzhou University, and Professor Nie Zhihong of Fudan University reported a nano-assembly of carbon honeycomb dots (CDs) that responds to tumor-associated fibroblasts (CAFs) and used it for the delivery of multiple therapeutic drugs Carry out spatial planning and enhance anti-tumor chemotherapy and immunotherapy.

Key points of this article:

(1) In the experiment, doxorubicin (DOX) and immunotherapy enhancers (Fe ions) were fixed on the surface of CDs, and tumor microenvironment modifiers (Losartan, LOS) were wrapped in the holes. Studies have shown that the drug-loaded nano-assembly can respond to CAFs to break down into single CDs, and then release LOS to alleviate interstitial formation and hypoxic environment.

(2) Subsequently, CDs loaded with DOX and Fe ions can effectively penetrate into the tumor and trigger a strengthened immune response. In vitro and in vivo studies have shown that the nano-assembly has the effects of achieving effective T cell infiltration, tumor growth inhibition and lung metastasis prevention, thereby providing a new therapeutic platform for combating solid tumor stromal hyperplasia.

references:

Lin Hou. et al. Transformable Honeycomb-like Nanoassemblies of Carbon Dots for Regulated Multisite Delivery and Enhanced Antitumor Chemoimmunotherapy. Angewandte Chemie International Edition. 2020

DOI: 10.1002/anie.202014397

https://onlinelibrary.wiley.com/doi/10.1002/anie.202014397

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