Nanomaterials and the immunological behavior of the immune system provide a theoretical basis for the development of immunotherapy methods based on nano-vaccine. Professor Li Yanmei of Tsinghua University and researcher Yu Xuefeng of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences systematically studied the immune-enhancing effects of black phosphorus nanosheets (BPs) in vivo and in vitro, and proposed a new and effective multifunctional nano adjuvant.



Key points of this article:
(1) The experiment uses the phenylalanine-lysine-phenylalanine (FKF) tripeptide modified epitope to simply coat BPs to prepare the FKF-OVAp@BP nano-vaccine, which has high loading capacity , Efficient drug delivery, ability to activate dendritic cells (DC) and good biocompatibility, which can be used for cancer immunotherapy. In a mouse model, the nano-vaccine can induce effective anti-tumor cell immunity through systemic immunization, and significantly enhance the therapeutic effect of checkpoint blockade (CPB) on melanoma.



(2) In addition, the near-infrared (NIR) photothermal effect of BPs can also provide a favorable immune microenvironment for improving local immunity. In summary, this research provides a new strategy for the use of nano adjuvants to combine immune activity and photothermal effect to enhance cancer immunotherapy, and is expected to further promote the development and application of multifunctional auxiliary nanomaterials for cancer treatment .



references:
Wen-Hao Li. et al. Black Phosphorous Nanosheet: A Novel Immune-Potentiating Nanoadjuvant for Near-Infrared-Improved Immunotherapy. Biomaterials. 2021
https://www.sciencedirect.com/science/article/pii/S0142961221001447