Surgical resection remains the first-line treatment for solid tumors. However, postoperative recurrence driven by residual tumor cells and an immunosuppressive microenvironment continues to challenge long-term patient survival. This study proposes an implantable fibrous scaffold functionalized with MnOx nanozymes to prevent tumor recurrence. The dual enzyme-mimicking activity of MnOx nanozymes endows the scaffold with immunomodulatory functions. On one hand, the peroxidase-like activity of MnOx nanozymes catalyzes the production of cytotoxic hydroxyl radicals, thereby triggering immunogenic cell death and antigen release.On the other hand, its catalase-like activity helps alleviate hypoxia by decomposing H₂O₂ to generate O₂, thereby reprogramming macrophages into a pro-inflammatory M1 phenotype. At the same time, the released Mn²⁺ ions can act as an effective immune adjuvant, promoting the recruitment and activation of immune cells. This synergistic immune-regulating cascade allows the scaffold to establish a persistent local immune microenvironment.Both in vitro and in vivo evaluations have confirmed that this MnOx-functionalized scaffold can trigger a robust antitumor immune response and effectively prevent postoperative recurrence without the need for exogenous immune stimulants. This work highlights a material-based immunotherapy strategy that leverages the inherent catalytic and immunomodulatory properties of nanozymes to design bioactive scaffolds for postoperative cancer treatment.

Original link

Immunomodulatory Fibrous Scaffold with Dual Enzyme-Mimic Activities Prevents Postsurgical Tumor Recurrence

Pub Date : 2025-12-27

DOI: 10.1002/advs.202519431

Xiaoyi Zhao,  Zhuolong Jiao,  Yue Wang,  Huimeng Gu,  Longfei Li,  Jian Song, Chen Xu,  Jiajia Xue,  Fu‐Jian Xu,  Nana Zhao