The process of bone remodeling is coordinated by the interactions between cells and the biomolecules they secrete within the bone ion microenvironment. The osteoinductive properties of demineralized organic bone matrix and related biological factors have been well studied, but the effects of the bone ionic environment on cell differentiation and osteogenesis remain to be explored. In this study, inorganic bone components were extracted and isolated using a low-temperature method, and for the first time, the positive effects of the bone ionic microenvironment on cell differentiation and its regulatory effects on bone immune response were investigated, confirming that this environment can promote osteogenesis and mineralization in relevant cells.

As a mineralized tissue, bone is constantly undergoing dynamic remodeling, a process that involves the mineralization and demineralization of the bone matrix and is regulated by cellular and biomolecular interactions mediated by the bone ion microenvironment. Currently, research on the osteoinductive properties of demineralized organic bone matrix and various biological factors has been relatively in-depth; however, there remains a considerable gap in understanding the specific effects of the bone ionic environment on cell differentiation and the osteogenesis process.

Thought Extension

This study fills the knowledge gap regarding the impact of the bone ion microenvironment on osteogenesis and bone immunity, providing a novel research entry point in the field of bone tissue engineering. Future research could further explore the deeper molecular mechanisms by which the bone ion microenvironment regulates bone remodeling, and based on this, develop bone tissue repair materials and strategies that are more in line with physiological conditions.

Original Source

Journal：Biomaterials（IF 12.9）

Pub Date：2023-11-29

DOI：10.1016/j.biomaterials.2023.122410

作者：Yuqing Mu、Zhibin Du、Wendong Gao、Lan Xiao、Ross Crawford、Yin Xiao