Academic Frontier
Bioactive Materials | Titanium surfaces use porous silicate diene nanofilms containing tetrabasic elements to enhance antibacterial activity and osteointegration ability
QQ Academic Group: 1092348845
Detailed
Bacterial infections, peri-implant inflammation, and malosseointegration are the main causes of titanium (Ti)-based implant failure. Surface functionalization offers a simple and effective strategy to overcome these challenges. In this study, we developed a multifunctional coating based on porous graphitiene (GDY) nanofilms loaded with shikonin (Skn). GDY is synthesized on the surface of titanium through copper-catalytic reactions, forming porous nanostructures. After Skn loading, tannins (TA) and poly(N-isopropionylamino) (pNIPAM) composites are superimposed to form the Ti-GDY@Skn-TP system. After near-infrared (NIR) irradiation, GDY coatings induce localized photothermal effects that are sufficient to destroy bacteria. At the same time, the thermal-response release of Skn inhibits early inflammation and promotes osseointegration by regulating macrophage polarization and inflammatory cytokine secretion. In vivo studies confirm that Ti-GDY@Skn-TP implants are effective in eliminating bacterial infections, mitigating acute inflammation, and enhancing bone tissue regeneration and implant integration. This versatile approach offers a promising strategy for Ti-based surface modification of biomedical implants.
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