This review focuses on the research and analysis of the microenvironment for enhancing bone synthesis and bone healing, elaborating on the physiological process of bone healing and the interfering factors, summarizing the existing regulatory research methods for bone healing, clarifying the existing research challenges in the field, and systematically integrating the research progress in the field of bone healing. This provides theoretical references for the analysis of bone healing mechanisms and subsequent basic research.
01 Research Background
Bone healing is a core research direction in the field of orthopedics. Its natural process is achieved through multi-stage physiological reactions to repair bone functions. However, imbalances in inflammatory states and the lack of necessary repair substances can hinder the normal progress of bone healing. Conducting related basic research has significant scientific value.
02 Main Content
This section explains the physiological processes and functions of each stage of bone healing, analyzes the key factors that interfere with the healing process, summarizes the multi-dimensional regulatory research methods for bone healing at present, and points out the research difficulties in the characterization of local microenvironments and the delivery of bioactive molecules in the body. It also systematically summarizes the existing research results in the field.
03 Research Design
This study is a review-type research. It focuses on the monitoring and intervention of the microenvironment for bone healing, and integrates and summarizes the published research results in related fields to outline the research context, influencing factors, regulatory strategies, and existing problems in bone healing, forming a systematic research summary.
04 Results
The complete physiological stages of bone healing have been clarified, the core factors affecting the healing process have been defined, multiple types of regulatory strategies such as biochemical regulation, biomechanical optimization, and application of regenerative technologies have been summarized, and the current main research challenges of precise characterization of local microenvironments and precise regulation of bioactive molecule delivery in the body have been determined. This provides a systematic reference for the research in the field.
05 Extension of Thoughts

Future research can focus on exploring precise characterization methods of the local microenvironment of bone healing, conducting in-depth research on the precise regulatory pathways of bioactive molecule delivery in the body, further analyzing the internal regulatory mechanism of bone healing, and improving the basic research system in the field of bone healing.

Original source:
1. Journal: Bone Research
2. Publication date: 2025-11-11
3. DOI: 10.1038/s41413-025-00466-5
4. Authors: Gaoxiang Xu, Junyang Chen, Zhikang Xiao, Jianzhong Xu, Licheng Zhang, Peifu Tang