This study investigated a locally injectable dual-functional hydrogel system, aiming to simultaneously address periodontitis and myocardial infarction, two inflammatory diseases with a bidirectional correlation, through a single treatment approach. This work developed a novel protein-loaded antibacterial hydrogel that not only effectively controls local periodontal inflammation and promotes alveolar bone regeneration, but also, by regulating the oral microbiome-immune system axis, provides systemic treatment and repair for distant myocardial infarction, offering a new non-invasive strategy for the treatment of co-morbid diseases. The related research was published in the international journal "Bioactive Materials".
Key Innovation Points
01 Innovative Treatment Strategy
The first to propose and validate a combined treatment approach of "local periodontal injection and systemic heart repair". This strategy breaks through the limitations of traditional single-organ treatment and achieves "two birds with one stone" through intervention in the periodontal-heart inflammation axis, providing a new paradigm for the treatment of diseases with co-morbidity associations. R&D Team: Qinfeng Ding, Yilong Teng, Hong Zhu, Zhitong Jia, Shuo Xu, Bin Hu, Boyan Chen, Jiewen Dai, Jian Sun, Ping Nie, Zhixiang Liu, Qijing Chen, Xudong Wang, Xiaoyang Xu, Xueqing Zhang, Shengzhong Duan