There are numerous micro/nano-scale fluid channels between/cwithin cells, maintaining the essential mass transfer process and ensuring the normal operation of the organism. However, due to the inherent Prandtl-Riley instability, the artificial construction and simulation of such fully liquid channels remain a challenging task. Here, we introduce a new "quasi-static stretching" method, applied to a liquid bridge in another immiscible liquid, with the liquid/liquid interface controlled by interface nanoparticles-polymer composites. These components have the characteristics of reconfigurable and adjustable interference networks, enabling the gradual stretching of the channel at the liquid bridge size. We established a selection rule covering the input components that generate ultrafine liquid channels during the stretching process. The superior flexibility and moderate entanglement or cross-linking of the polymer chains in the nanoparticle-polymer microstructure enable the liquid bridge to have plastic deformation ability, allowing the channel to advance forward to hundreds of nanometers, using advanced technologies to reduce two orders of magnitude, approaching the size range of biomimetic bridges. Additionally, by controlling the flow of mass transfer in the channel, we achieved a biomimetic tube-like analogue - the liquid bridge-based channel, verifying the biomimetic functions - intercellular mitochondrial rescue and separation of immunotherapy. These simulations may provide a potential framework for understanding the cell processes mediated by tubular structures in biophysics. This research was published under the title "Biomimetic Nanometer-Sized All-Liquid Channels" in Advanced Materials.
References:
DOI: 10.1002/adma.20252224