Micro-nano motors have the potential to achieve remote operation in complex biological environments. However, integrating robust barrier penetration, real-time tracking, and effective therapeutic systems into the motion system remains a formidable translational challenge. Here, we designed a sequence magnetically-driven and optically-imaged biological hybrid micro-motor (BAM) for precise tumor treatment. BAM consists of two components: the magnetically-driven bacteriophage (AMB-1), which achieves tumor autonomy through chemotaxis driven by hypoxia and external magnetic field navigation; and extracellular biomineralized Ag2S quantum dots, serving as near-infrared (NIR)-II fluorescent imaging agents and photothermal converters. In vivo studies demonstrated that BAMs can migrate to the hypoxic core of tumors through the synergistic effect of chemotaxis-driven and magnetic-driven targeting, which can be monitored by NIR-II fluorescence imaging. Additionally, as a photothermal therapeutic agent, BAMs effectively induce tumor cell apoptosis and inhibit tumor growth through photothermal conversion. This innovative BAM platform not only overcomes passive diffusion but also provides precise therapeutic agents for abnormal tissues by integrating magnetic permeability, near-infrared II imaging, and photothermal therapy, demonstrating the potential of the biological hybrid system. This research was published in ACS Nano under the title "Engineered Magnetobacterial Microrobots with Tunable Self-Mineralization for Precise Imaging-Guided Photothermal Therapy."
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DOI: 10.1021/acsnano.5c19758