Punctate membrane melanoma is a common intraocular malignant tumor with a high mortality rate and liver metastasis, which is associated with the lack of sensitive and non-invasive treatment methods. To address the imaging diagnosis and treatment challenges of punctate membrane melanoma, a novel nanoplatform was developed by integrating aggregation-induced emission photosensitizers with two-dimensional MXene nanosheets (MX@PEG-MeoTTPy). This nanoplatform exhibits unique characteristics and multiple functions, including excellent biocompatibility, efficient generation of type I reactive oxygen species, high-quality fluorescence biological imaging, mild near-infrared (NIR) photothermal properties, and excellent cell absorption capacity. Additionally, a thermosensitive hydrogel composite material was designed, encapsulating the nanosheets to achieve a gel-sol transformation induced by near-infrared irradiation and tumor microenvironment, with controlled and sustained release within 72 hours. This nanoplatform combines synergistic mild photothermal therapy and photodynamic therapy, achieving precise and sustained tumor ablation through thermal cell death. Both in vitro and in vivo studies have confirmed that this nanosystem is an effective therapeutic agent for dual-modal imaging-guided synergistic treatment, providing comprehensive treatment strategies for intraocular tumors and demonstrating significant potential in clinical applications for the treatment of choroidal melanoma. This research was published in Nano-Micro Letters under the title "Aggregation-Induced-Emission Luminogens Functionalized MXene Nanosheets for Stimuli-Responsive Hydrogel in Pyroptosis-Mediated Choroidal Melanoma Therapy".
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DOI: 10.1007/s40820-026-02077-z