The enhanced drug-resistant bacteria challenge the existing skin disinfection strategies, while the non-degradable nature of traditional cationic antibacterial agents limits their clinical safety. Traditional photodynamic therapy is limited by complex application requirements. To address these limitations, we developed a biodegradable, sunlight-activated photodynamic cationic nano-spray agent (NP PORPMn). Under environmentally friendly and easily accessible sunlight exposure (NP PORPMn +L), NP PORPMn efficiently generates reactive oxygen species and works synergistically with its quaternary ammonium cations, exerting a potent antibacterial effect. This dual action significantly reduces the inflammatory response in the infected microenvironment and accelerates the healing of infected wounds caused by Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Skin disinfection experiments further demonstrated that NP PORPMn +L can eliminate pathogenic bacteria and resident microbial communities on the skin surface. This study proposes an innovative, biodegradable, and clinically safe nano-spray platform, leveraging the convenience of sunlight activation, providing a promising strategy for combating antibiotic-resistant infections. This research was published under the title "Biodegradable Nanospray for Sunlight-Activated Photodynamic Antibacterial Therapy and Wound Healing" in Advanced Materials.
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DOI: 10.1002/adma.7291