Trauma is prone to causing extensive skin tissue defects, accompanied by bacterial infection, excessive oxidative stress and disordered inflammation, leading to delayed healing and scar formation. This study presents a core-shell structure microneedle patch, aiming to address these challenges through integrated therapeutic functions. The microneedle shell contains melanin nanoparticles chelated with copper ions, used to control bacterial infection, while the microneedle core is filled with sage acid B microparticles to reduce scar formation. In vitro analysis shows that this patch can effectively eliminate reactive oxygen species (ROS), inhibit bacterial growth, and promote fibroblast migration and angiogenesis. Computational simulations further reveal its controlled drug diffusion, ensuring sustained therapeutic effects. In vivo experiments using wound models infected with Staphylococcus aureus confirmed the effectiveness of this patch in accelerating wound closure, reducing inflammation and alleviating scar formation. Histopathological analysis and RNA sequencing emphasized its role in regulating inflammatory and collagen deposition pathways, while promoting balanced tissue regeneration. The microneedle system provides a promising platform for wound healing and scar prevention, combining targeted drug delivery with multifunctional therapeutic effects. This research was published in ACS Nano under the title "Multifunctional Microneedle Patch with Antibacterial, Antioxidant and Pro-Regenerative Properties for Scarless Wound Healing".
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DOI: 10.1021/acsnano.6c01964