To address the sequential treatment requirements for infectious bone defects, which involve both antibacterial and bone regeneration, this study has developed a near-infrared responsive Janus dual-layer periosteum scaffold. This design enables the spatial separation of photothermal antibacterial and piezoelectric osteogenic functions. By switching between different near-infrared irradiation modes, both in vitro and in vivo experiments have confirmed its ability to synergistically complete antibacterial, immune regulation, and bone mineralization promotion, providing a novel material strategy for the temporal regulation of the microenvironment for the repair of infected bone defects.
01 Research Background

The repair process of infectious bone defects has phased functional requirements, necessitating the sequential completion of infection control and bone tissue regeneration. Piezoelectric materials can convert external stimuli into biological electrical signals, providing a feasible approach for regulating the antibacterial and osteogenic processes. However, traditional piezoelectric scaffolds have their multiple functions coupled together, making it impossible to achieve functional separation and difficult to match the specific requirements of different repair stages of bone defects.

Original source:
1. Journal: Bioactive Materials
2. Publication date: April 2, 2026
3. DOI: 10.1016/j.bioactmat.2026.03.046
4. Authors: Ying Yin, Yuting Cai, Pengrui Dang, Wenyi Zeng, Lu Wang, Xu Yan, Zhengtang Luo, Wenwen Liu, Yangzhi Zhu, Lili Chen, Chenguang Zhang