AFM: Conductive hydrogel platform for neuron growth and electrophysiological recording

University of Illinois Ralph G. Nuzzo and others have prepared a biocompatible conductive hydrogel platform for neuron growth and electrophysiological recording to conduct electricity. The 3D periodic micro-scaffold is manufactured using a particle-free direct ink writing method for neuron growth and electrophysiological recording platform. The polyhydroxyethyl methacrylate/pyrrole ink is then chemically polymerized in situ of the pyrrole, and hydrogel printing can be performed through a nozzle as small as 1 μm.



Key points of this article:
1) These conductive hydrogels can pattern complex 2D and 3D structures, and have good biocompatibility with the test cell culture (survival rate after 7 days is about 94.5%).



2) The hydrogel array promotes the extensive outgrowth of cultured sea hare foot ganglion neurons. This platform allows extracellular electrophysiological recording of steady state and stimulated electrical neuron activity. All in all, this 3D conductive ink printing process can prepare biocompatible and micron-scale structures to create a customized in vitro electrophysiological recording platform.

references:
Wang,C., et al., 3D Particle-Free Printing of Biocompatible Conductive HydrogelPlatforms for Neuron Growth and Electrophysiological Recording. Adv. Funct.Mater. 2021, 2010246.

https://doi.org/10.1002/adfm.202010246

Source of information: Wonders

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