IF 12.1! pH-Switchable Multi-Enzyme Mimicry via Liquid Metal Nanozymes

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Liquid metals (LMs) possess unique reversible morphologies and tunable electronic properties, making them a promising platform for designing advanced nanozymes. The catalytic activity of nanozymes is often highly dependent on the environmental pH. In this study, a magnetic LM-buffered iron oxide nanozyme (FeOx@EGaIn) with pH-switchable enzyme activity was designed, where the LM serves as an electron transfer substrate, effectively enhancing catalytic efficiency. Due to the different oxidation forms and local electronic properties of iron oxide in acidic and alkaline systems,FeOx@EGaIn nanozyme exhibits excellent peroxidase (POD) catalytic activity under acidic conditions (Km = 2.12 mM, vmax = 1.96 × 10−6 M s−1), and converts to catalase (CAT) activity under neutral to alkaline conditions, showing high catalytic stability. Its unique magnetic responsiveness also provides a more convenient possibility for catalyst recovery.In addition, the switchable enzyme activity of nanozymes provides new avenues for biosensing applications, especially in the detection of a wide range of pH-responsive biomolecules. Using liquid metal nanozymes as a colorimetric sensing platform for dynamic detection of biomolecules reveals the key role of the electronic microenvironment in regulating nanozyme catalytic activity and also expands the potential applications of liquid metals in catalysis, sensing detection, and the biomedical field.

Original link

pH-Switchable Multi-Enzyme-Mimicking via Liquid Metal Nanozyme

Pub Date : 2025-05-26

DOI: 10.1002/smll.202502752

Yuhe Shen,  Xiaojian Xu,  Ruizhe Xing,  Yuefei Wang,  Rongxin Su,  Jie Kong,Renliang Huang,  Michael David Dickey,  Wei Qi