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The development of micro- and nano-robots has greatly increased the demand for intelligent multifunctional machines in biomedical applications, but most micro-robot systems struggle to achieve the properties required for these applications. We introduce enzyme microbubble robots with steerable motion, enhanced biodegradability, high in vivo imaging contrast, and effective targeting and penetration of diseased sites.These micro-robots use natural protein shells modified with urease, decomposing biologically available urea to achieve autonomous propulsion, while the internal microbubbles serve as ultrasound imaging contrast agents for deep tissue imaging and navigation. The integration of magnetic nanoparticles enables imaging-guided magnetic control, and hydrogen peroxide functionalization promotes chemotactic movement toward hydrogen peroxide gradients, guiding the robots to tumor sites. Focused ultrasound triggers the collapse of the robot shells and the inertial cavitation of the released microbubbles, generating mechanical forces to enhance the penetration of therapeutic payloads. In vivo studies confirmed the tumor-targeting and therapeutic effects of these robots, showing enhanced anti-tumor efficacy. This multifunctional microbubble robot platform has the potential to transform medical intervention and precision therapy.
