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The rapid emergence of antimicrobial resistance has become a major global public health challenge, especially for Gram-negative pathogenic bacteria such as Pseudomonas aeruginosa, which, due to its inherent low permeability of the outer membrane and high expression of efflux pumps, develops resistance to multiple traditional antibiotics, posing a significant problem for clinical infection treatment. Since the 1980s, the development of new antibiotics targeting Gram-negative bacteria has been slow. How to make existing antibiotics regain efficacy against resistant bacteria has become the key research issue in the field of antimicrobials. Recently, a research team from Beijing University of Chemical Technology published a significant study in "Nature Communications", successfully constructing a biomimetic pH-responsive cerium-carboxyl penicillin @ garlic-derived extracellular vesicle nanoplatform (Ce-Car@EV NPs). By ingeniously integrating the advantages of metal-drug coordination nanoparticles and plant-derived extracellular vesicles, it efficiently reverses the resistance of Pseudomonas aeruginosa to carboxyl penicillin, providing a new nanomedicine strategy for solving the problem of antimicrobial resistance.
Original link: doi:10.1038/s41467-026-69712-6
