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This study developed a pH-responsive hydrogel adhesive based on mussel foot proteins to improve the bone-implant integration effect in osteoporosis. Through dual-interface adhesion and microenvironment-responsive drug release, it achieved multi-dimensional coordinated regulation of bone, blood vessels, and immunity, enhancing interface stability and tissue regeneration level.
01 Research Background
The bone matrix in osteoporosis reduces the initial fixation stability of orthopedic implants. Abnormal macrophage polarization at the interface leads to imbalance in bone immune homeostasis and insufficient vascularization, which easily causes the failure of implant function. Therefore, a multifunctional adhesive material adapted to the pathological microenvironment is urgently needed.
02 Main Content
Inspired by mussel foot proteins, a pH-responsive multifunctional hydrogel adhesive was prepared. The catechol structure was used to achieve stable dual-interface bonding between metal implants and bone matrix. In the inflammatory microenvironment of osteoporosis, the active components were released controllably and regulated the metabolism and inflammatory signaling pathways, reshaping the bone-blood-vessel-immune microenvironment, and promoting bone regeneration and angiogenesis.
03 Research Design
A hydrogel system was constructed based on pseudo-mussel foot proteins, and borate ester bonds and metal-phenol coordination structures were introduced. A dual-interface adhesion mechanism was designed, combining the sequential release strategies of active ions and pro-angiogenic and osteogenic peptides, for integrated design in terms of mechanical fixation, immune regulation, angiogenesis, and osteogenic induction.
04 Results
This hydrogel can effectively enhance the fixation effect of the implant and optimize the integration state of bone-implant interface. By regulating glutathione metabolism, inhibiting related inflammatory pathways, and abnormal macrophage polarization, it reduces the inflammatory response, simultaneously promoting angiogenesis and bone regeneration, and improving the implant adaptability in pathological conditions.
05 Extension of Ideas
This provides a new direction for the development of biomimetic adhesion materials for bone implant interfaces in pathological microenvironments and offers theoretical and experimental support for the design of biomaterials for multi-dimensional coordinated regulation of bone, blood vessels, and immunity.
Original source:
1. Journal: Advanced Materials
2. Publication date: November 5, 2025
3. DOI: 10.1002/adma.202511840
4. Authors: Wentao Wang, Zhenyu Li, Siming Zhang, Yue Ma, Lei Yu, Qidong Zhang, Guoqing Pan, Dechun Geng, Chen Zhu, Jiaxiang Bai
