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This research was published in the top international materials journal, Advanced Materials. The study focused on improving the immunosuppressive treatment after kidney transplantation. Facing the challenges of a narrow therapeutic window for the core drug tacrolimus and the difficulty in long-term medication management, the research team innovatively developed an injectable self-assembling peptide hydrogel drug delivery system. This system adopts a "multicomponent assembly" strategy, encapsulating the drug in microcrystalline form, aiming to achieve long-lasting and controllable release. Animal experiments demonstrated that a single injection of this hydrogel could effectively inhibit rejection reactions, significantly prolong the survival of the transplanted kidney, and exhibit good tissue protection and biological safety. This work provides a novel and promising material-based strategy for immunotherapy in organ transplantation.
Key innovations
01 Precise and sustained release control
This study abandoned the traditional drug mixing method and pioneered the "multicomponent assembly" strategy, embedding the drug microcrystals as independent phases into the hydrogel network to construct a structurally precise "drug depot". This design enables more precise and sustained control of the drug release rate.
02 Long-acting local immunosuppressive therapy
The research combined the injectable hydrogel with local administration, creating a new "one-time injection, long-term maintenance" immunosuppression model. This method is expected to transform daily oral medication into a convenient local treatment, enhancing local efficacy while reducing systemic side effects risks while improving compliance.
Journal name: Advanced Materials Publication date: 2026-03-08 DOI: 10.1002/adma.72590 Research team: Di Wei, Huilei Dong, Wenjing Huang, Wei Xie, Shuang Chen, Geng Zhang, Dan Yuan, Zheng Zhu, Jianlin Yuan, Junfeng Shi
