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This study investigated a type of bio-heterogeneous integrated reconstituted collagen hydrogel named CAP@MXene/CuTCPP, which was used to treat wounds infected by multi-drug resistant bacteria (particularly MRSA). The research was published in the journal "Bioactive Materials". The research team constructed a dynamic borate ester bond-crosslinked hydrogel network, combining the MXene/CuTCPP bio-heterogeneous junction with the reconstituted collagen protein. Under near-infrared light irradiation, this hydrogel achieved efficient clearance of MRSA and its biofilm through the synergistic effects of photothermal effect, photodynamic effect, and peroxidase-like activity. More importantly, in the in vivo environment, this hydrogel not only served as a biomimetic extracellular matrix to support tissue regeneration, but also effectively regulated macrophages to polarize from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype, thereby significantly promoting angiogenesis and wound closure. This research provided a new design concept for developing wound dressings with both efficient antibacterial and immunomodulatory functions.
Journal Name: Bioactive Materials
Publication Date: March 11, 2026
DOI: 10.1016/j.bioactmat.2026.03.007 R & D team: Chongyi Li, Zewen Chang, Yuxi Zhang, Shihong Shen, Lin Liu, Dan Zeng, Daidi Fan
