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This article, reported by Prof. Deng Jun, Prof. Luo Xigong, and Prof. Zhou Binghua from Southwest Hospital of the Army Medical University, from the perspective of biomaterials, has its highlights not just in "creating a nanoscale healing-promoting system", but in truly integrating the remodeling of the microenvironment and the activation of endogenous stem cells into a sequential therapeutic logic. The authors discovered that one of the key factors for the chronic non-healing of diabetic chronic wounds is that the inflammatory microenvironment continuously suppresses the proliferation and differentiation ability of epidermal stem cells (EpSCs); therefore, they designed a core-shell "nanocascade workshop" Cu5.4O@LL-37/pDNA. The front end relies on ultra-small copper-based nanoenzymes to eliminate ROS and alleviate inflammation, while the rear end uses LL-37 to assist in the delivery of plasmids and continuously expresses P311, thereby reactivating the regeneration program of EpSCs. As a result, it significantly accelerated re-epithelialization, collagen deposition, and wound closure in both diabetic wounds and infected wounds.
In a more concise way, this work proposes a "soil modification first, then seed activation" material strategy: it is not merely anti-inflammatory or merely gene delivery, but rather it first transforms the damaged wound ecological environment into one conducive to regeneration, and then continuously activates the function of epidermal stem cells. Therefore, the therapeutic effect is more lasting and more like precise regenerative treatment.
The related research was published in Advanced Materials under the title "Nanocascade Engineering Workshop for Synergistic Microenvironment Reprogramming and EpSC Revitalization in Precise Diabetic Wound Therapy".
