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Recently, the team of the Cardiac Pacing Electrophysiology Department of the First Affiliated Hospital of Xinjiang Medical University has made significant progress in a research project. The related research results were published online on March 12, 2026, in the international authoritative journal "Materials Today Bio" (with an impact factor of 10.2). Under the guidance of Professor Tang Baopeng and Professor Zhou Xianhui from the Cardiac Pacing Electrophysiology Department, doctoral student Song Jie and Bo Yakun were the co-first authors, while Zhou Xianhui, Tang Baopeng, Wang Chao, and Wu Heting were the co-corresponding authors. The writing and revision of the paper were also guided by Professor Fan Zhongxiong from Xinjiang University.
This research directly addresses the key clinical bottleneck of "structural damage + electrical functional imbalance" in post-myocardial infarction repair, which is difficult to achieve phased restoration. Current treatments mainly focus on reperfusion or drug intervention, although they can partially improve cardiac function, they lack effective means for the interruption of electrical conduction in the infarcted area and the risk of arrhythmia. Based on the clinical demand for "electrical conduction reconstruction and rhythm stability" in the field of cardiac pacing and electrophysiology, the research team proposed an integrated repair strategy of "electrical conduction reconstruction + staged response drug delivery + microenvironment multi-pathway regulation", and constructed an injectable intelligent conductive hydrogel system PGO/CAM@Sal.
This system embeds a polypyrrole conductive network into the hydrogel framework and introduces a triple-response mechanism of pH/ROS/MMP9 to achieve dynamic matching of material properties with the course of myocardial infarction: On the one hand, this hydrogel has conductive properties close to natural myocardium and can "bridge" the broken electrical signal pathways in the infarcted area, restoring myocardial electrical synchrony; on the other hand, through the construction of a responsive network through dynamic covalent bonds and combined with red ginsenoside (Sal) microspheres loaded by microfluidics, the drug is precisely released at different pathological stages, thereby synergistically regulating inflammatory responses, oxidative stress, and fibrosis processes. This system not only provides structural support but also achieves dual-dimensional collaborative repair of "electrical activity - biological function".
Paper link: https://doi.org/10.1016/j.mtbio.2026.103016
