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The hydrophobic integration based on sucralfate (SHIELD) is developed as a modular oral drug delivery platform for intestinal mucosa and nanoparticle delivery. SHIELD covers the entire gastrointestinal tract and can locally retain and preserve therapeutic nanoparticles, subsequently achieving complete excretion. When combined with CeO2 nanoparticles, SHIELD-CeO2 exhibits significant therapeutic effects in two different intestinal injury models: dextran sulfate sodium (DSS)-induced colitis and radiation-induced intestinal disease. This research was published in Advanced Materials under the title "Orally Administered Nanoparticle Coacervate for Therapeutic Coating of the Entire Gastrointestinal Tract".
Summary
When oral nanoparticles enter the gastrointestinal tract, they are often washed away by stomach acid or decomposed by enzymes before they can take effect. This study incorporated antioxidant nanoparticles into a clinical drug called "sucralfate", which was processed through acidification and dehydration to form a dry powder. Animal experiments revealed that when this powder was swallowed, it would quickly turn into a uniform paste-like coating upon contact with intestinal fluid, covering the entire gastrointestinal tract like a wall, and complete the encapsulation within 6 hours. It was excreted in the feces 12 hours later. The most crucial aspect is that this physical barrier not only prevents the nanoparticles from being engulfed by cells but also avoids the leakage of metal ions into the bloodstream. Taking cerium oxide nanoparticles as an example, the coated particles can significantly alleviate weight loss, repair the villus structure, reduce oxidative damage markers, regulate the intestinal microbiota and promote stem cell regeneration, regardless of whether it is for immune-mediated colitis or radiation-induced intestinal damage. This delivery platform based on sucralfate is also compatible with various nanoparticles such as gold and iron, and has both therapeutic and imaging functions. References:
DOI: 10.1002/adma.202514708
