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Quick and effective bleeding control remains a major challenge in trauma and surgical care, especially for complex or non-compressible wounds. Existing hemostatic biomaterials often have a monolithic, low-porosity structure, limited injectability, and rely on external stimuli, which limits their clinical utility. This study introduces a shape-shifting nano-engineered hydrogel tape system to address these limitations. The double-layer hydrogel tape consists of an active layer and a non-active layer. Under physiological conditions, it forms a porous, interconnected network through temperature-induced curling and subsequent aggregation. To achieve hemostatic function, the surface of the tape is functionalized with rapontin (nSi)-dopamine (PDA) nanoparticles, imparting procoagulant and adhesion properties. The shape change increases the effective surface area for blood-matter interaction, while the combination of thermally responsive driving, physical interlocking, and bioactive surface coatings forms a multifunctional platform that integrates mechanical and biochemical cues to accelerate thrombosis. The composite system has high injectability, enhanced tissue adhesion, and significantly accelerates hemostasis, with an in vitro clotting time reduction of 67%. These effects have been further validated in vivo, showing a 80% reduction in clotting time and a 60% reduction in blood loss. This integrated strategy highlights the potential of shape-shifting materials as rapid injectable hemostatic agents and provides an innovative approach for managing bleeding, thereby improving clinical outcomes. This research was published under the title "Shape-Morphing Nanoengineered Hydrogel Ribbons as Hemostat" in Advanced Functional Materials.
Reference News: DOI: 10.1002/adfm.202521053
