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Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. Current treatment methods are often limited by side effects and high recurrence rates. This study introduces a supermicro platinum nanocluster artificial enzyme (Pt NE) for effective psoriasis treatment and recurrence prevention. Pt NE exhibits multi-enzyme mimetic activity, including superoxide dismutase, catalase, and glutathione peroxidase-like enzymes, with an overall antioxidant capacity 5 times higher than that of gold or copper analogues. They have superior skin penetration rates (14.27% higher than gold and copper), enabling the efficient removal and regulation of inflammatory microenvironments. In vivo, Pt NEs achieved complete relief of psoriasis symptoms, similar to commercial calcipotriol/betamethasone ointment, but without steroid-related adverse reactions. Mechanistically, Pt NE regulates immunity by down-regulating pro-inflammatory genes and up-regulating genes related to proliferation inhibition and apoptosis. Excellent biocompatibility was observed, with no detectable organ damage or systemic toxicity. This study proposes a safe, effective, and cost-effective anesthesia strategy with strong clinical translational potential in psoriasis management. This study was published in ACS Nano under the title "Ultrasmall Platinum Nanoclusters Modulating Dysregulated Reactive Oxide Species and Immunity for Psoriasis Therapy and Prevention".
References:
DOI: 10.1021/acsnano.5c18716
