已传文件：photo/1773121782.png
Phototherapy provides a non-pharmacological method for wound healing, which is used in routine clinical practice. However, the wavelength-dependent absorption and scattering within the skin significantly reduce the penetration depth of visible light to the treatment target. In this study, we developed a programmable luminescent adhesive patch, mediated by tartrazine (Tar), for photochemical tissue bonding (PTB). Hyaluronic acid (HA) promotes transdermal delivery of Tar, improves the optical skin cleaning effect, and stabilizes its interaction with the photosensitizer. Optical skin cleaning enhances the penetration of visible light into the skin tissue, and the patch mechanically shrinks the wound gap while continuously emitting green light to photoinactivate rhodamine Bengal (RB) collagen cross-linking. In a mouse incision wound model, a single treatment can accelerate collagen fiber formation, increase interface tensile strength, and produce continuous wound edge adhesion, accompanied by collagen deposition in the tissue and regulation of inflammatory markers. These findings indicate its practical application in light-source wound closure, complementing sutures, and opening important pathways for the further application of biophotonics in dermatology and tissue regeneration.
This study was published in Advanced Functional Materials under the title "Strain-Programmable Luminescent Adhesive Patch With Tartrazine-Mediated Optical Skin Clearing for Photochemical Tissue Bonding". References:
DOI: 10.1002/adfm.202529087
