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To address the issue that orally administered nano-bio hybrid therapy easily loses probiotic activity and nanozyme function during gastrointestinal transport, researchers modified lactobacillus with cerium oxide nanozymes and then coated it with the EL100-55 enteric layer to create gut-gated nano-probiotic living nanozyme CeO2@LP@EL. This layered structure helps preserve hybrid integrity, bacterial survival, redox protection activity, and adhesion to epithelium after simulated digestion. In gut epithelial cells, it reduces oxidative stress and maintains antioxidant homeostasis.
In a cisplatin-induced acute kidney injury model, oral CeO2@LP@EL alleviated kidney dysfunction and tubule injury, while also repairing the gut barrier, reducing endotoxemia and inflammation, suppressing oxidative stress, reshaping gut microbiota, protecting mitochondria, and restoring relevant kidney transcription changes. The results suggest that gut gating can serve as a practical design principle for nano-bio hybrids, linking probiotic activity with nanozyme redox regulation and promoting gut-directed repair protection.
Reference:
DOI:10.1186/s12951-026-05162-y
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