Professor Tao Xutang of Shandong University AFM: MXene quantum dots for tumor treatment

Based Fenton or Class Fenton has become the treatment of tumors accurate research frontier response enhancement nanocatalyst intracellular oxidative stress. However, low catalytic efficiency, poor biocompatibility, and potential toxicity remain a challenge.

Achievements

Recently, Shandong Taixue the Tao Xu Tang Professor Hong Liu and Professor in the top international journal Advanced Functional Materials published entitled " Nonoxidized MXene Quantum Dots microexplosion the Prepared by Catalytic Method, for Cancer Therapy " papers. A titanium-based material with good biocompatibility is proposed for cancer treatment. Unoxidized MXene-Ti 3 C 2 T x quantum dots (NMQDs-Ti 3 C 2 T x ) were successfully prepared by the self-designed micro-explosion method . It has obvious inhibition and killing effect on cancer cells, and has good biocompatibility with normal cells. In addition, the inhibition rate of NMQDs-Ti 3 C 2 T x on the xenogeneic tumor transplantation model can reach 91.9% without damaging normal tissues. NMQDs-Ti 3 C 2 T x Ti ³⁺It can react with H 2 O 2 in the tumor microenvironment , and efficiently produce a large number of toxic hydroxyl free radicals, increase the tumor microvascular permeability, and synergistically kill cancer cells. This work will pave the way for the application of safe and reliable MXene-based materials in tumor catalytic therapy.

Figure  1 Schematic diagram of preparation of NMQDs-Ti 3 C 2 T x . 

Picture  2 The morphology of NMQDs-Ti 3 C 2 T x .

Picture  3 Schematic diagram of NMQDs-Ti 3 C 2 T x treatment of tumors.

Figure  4  Survival rate of different cancer cells and normal cells cultured with NMQDs-Ti 3 C 2 T x .

Figure  5  NMQDs-Ti 3 C 2 T x treatment of tumors in mice.

in conclusion

     The NMQDs-Ti 3 C 2 T x was prepared by the self-designed micro-explosion method . Ti ³⁺ in NMQDs-Ti 3 C 2 T x can effectively react with H 2 O 2 in the acidic microenvironment of tumors , efficiently generate highly toxic hydroxyl groups, destroy the integrity of tumor blood vessels and kill cancer cells. The cells have good biocompatibility. This work will expand the application of MXene -based materials in the catalytic treatment of tumors.

Original link:

https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202000308

Source: MXene Academic

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