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Manganese oxide nanoenzymes: MnO2, Mn3O4 NZs

Multi-enzyme activity: catalase-like, superoxide dismutase-like, glutathione-like peroxidase, with antioxidant function; its catalase-like activity can decompose H2O2 ultrasonic oxygen in tumor microenvironment To solve the hypoxia problem of photodynamic therapy, sonodynamic therapy, and radiation therapy for tumors; its glutathione peroxidase-like activity can consume the antioxidant glutathione GSH in the tumor microenvironment, thereby promoting the above-mentioned pro-oxidation Treatment; After reacting with H2O2 and GSH, the manganese oxide nanozyme is degraded to Mn2 +, which can promote the Fenton reaction, catalyze H2O2 to generate hydroxyl radicals, and further promote oxidation to treat tumors. At the same time, the Mn2 + produced has magnetic resonance imaging function; manganese oxide Usually has strong near-infrared light absorption capacity, which can be used for photothermal therapy and photoacoustic imaging; Mn3O4 has certain magnetic properties, which can be used for magnetic resonance imaging; decomposition of H2O2 to generate oxygen bubbles, which can be used for ultrasound imaging; can also be combined with chemotherapy drugs, Gene medicine, etc. to achieve combined therapy.