As a class of functional materials, ceria (CeO2) has received extensive attention in the field of nanozyme research. Benefiting from the catalytic properties of various types of enzymes such as peroxidase, oxidase, superoxide dismutase and phosphatase exhibited by CeO2 nanozymes, it is widely used in sensing analysis, energy environment, biomedicine and food safety. are favored and have achieved rich research results. In recent years, the research on the phosphatase-like catalytic activity of CeO2 nanozymes has made great progress. Based on the phosphatase catalytic properties of CeO2 nanozymes, excellent results have been achieved in the fields of biosensing, antibacterial and medical applications. However, there is still room for further research on the application of CeO2-like phosphatase catalytic activity. For example, how to easily and controlly prepare CeO2 nanoparticles with uniform morphology, ultra-small particle size and good dispersion; how to improve the high exposure of CeO2 nanoparticle phosphatase-specific catalytic crystal faces; how to expand CeO2-type phosphatases Scope of application of catalytic activity.