In the treatment of hypoxic tumors, oxygen-dependent photodynamic therapy (PDT) is quite limited. Here, Hongjun Wang from Stevens Institute of Technology in the United States and others have developed a new bimetallic two-phase Rh-based core-shell nanosystem (Au@Rh-ICG-CM) to solve the problem of tumor hypoxia and obtain high PDT. effectiveness.

Schematic diagram

Key points of this article:

1) This porous Au@Rh core-shell nanostructure is expected to exhibit catalase-like activity to effectively catalyze the generation of oxygen from endogenous hydrogen peroxide in tumors. Coating Au@Rh nanostructures with tumor cell membrane (CM) can achieve tumor targeting through homologous binding.

2) Due to the large pores of the Rh shell and the capturing ability of CM, the photosensitizer indocyanine green (ICG) was successfully loaded and held in the cavity of Au@Rh-CM. Au@Rh-ICG-CM has good biocompatibility, high tumor accumulation and excellent fluorescence and photoacoustic imaging performance.

3) The results of in vitro and in vivo experiments show that Au@Rh-ICG-CM can effectively convert endogenous hydrogen peroxide into oxygen, thereby increasing the production of tumor toxic singlet oxygen, thereby significantly increasing PDT. The mild photothermal effect of Au@Rh-ICG-CM also improves the PDT efficiency.

All in all, Au@Rh-ICG-CM integrates the advantages of hypoxia regulation function, tumor accumulation ability, dual-mode imaging and mild photothermal effect into a single nanosystem, which is expected to become a promising nanoplatform for enhancing cancer PDT .

references:

Jinping Wang, et al. A Porous Au@Rh Bimetallic Core--Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy, Adv. Mater., 2020.

DOI: 10.1002/adma.202001862

https://doi.org/10.1002/adma.202001862

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