Unhealed chronic wounds will produce a variety of bacteria and excessive proteolytic wound exudate, which can lead to multiple infections. Shan-hui Hsu, National Taiwan University of China, Tzu Chi University, and Niann-Tzyy Dai of the General Hospital of Tri-Services of China use bifunctional polyurethane (DF-PU) cross-linked with glycol chitosan and a biodegradable Schiff base as raw materials The crystal gel/hydrogel biomaterial with antibacterial function was prepared.

Key points of this article:

(1) Low temperature gel has abundant macropores and porosity of 86.5±1.6%, water absorption rate is 2730±400%, cell proliferation effect is 240%, and it has good antibacterial activity and biodegradability. The experiment used this material to treat a rat model of diabetic skin wounds, and found that 90.34±2.3% of the wound can be achieved by implanting a gel/hydrogel biomaterial with adipose stem cells on the wound and acupuncture around it. Close rate, granulation tissue and sufficient capillaries are formed within 8 days, and epithelial tissue will be completely regenerated.

(2) After acupuncture, the average surface temperature of animal wounds will increase by about 1-2°C. Experimental results show that the strategy of combining crystal gel/hydrogel biomaterials with acupuncture can activate C3a and C5a, promote the increase of cytokine SDF-1 and TGFβ1 secretion, and down-regulate the pro-inflammatory cytokines TNF-α and IL-1β In order to produce a synergistic immunomodulatory effect, this research also provides an effective new method for promoting tissue regeneration.

references:

Tsai-Yu Chen. et al. Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation. Biomaterials. 2020

https://www.sciencedirect.com/science/article/pii/S0142961220308541

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