ACS Nano of Wenzhou Medical University: Microenvironment triggered biodegradable hydrogel for imaging diagnosis and comprehensive treatment of intraocular choroid melanoma

Human choroidal melanoma (HCM) is one of the most common primary intraocular tumors and is prone to liver metastasis due to the lack of sensitive non-invasive treatment. For the imaging diagnosis and treatment of choroidal melanoma,

Jinhai Huang, Mei Yang, A-Yong Yu et al designed A micro-environment-triggered degradable hydrogel (RenP-ICG@pNIPAM: DOx-FA) based on ultra-small (<5 nm) rare earth nanoparticles (RENPs) with enhanced NIR-II luminescence.

Main points of this article:

1) Ultra-small diameter can significantly improve the NIR-II luminescence performance of RENPs. RENPs was encapsulated by a dual-response PNIPAM hydrogel, which released the drug in response to thermal energy and glutathione in a tumor microenvironment.

3) In addition, the biodegradability of hydrogel composites under physiological conditions is conducive to improving the effect of photothermal chemotherapy and reducing long-term biotoxicity.

In summary, hydrogels with enhanced NIR-II imaging and microenvironment-triggered metabolism may provide a promising strategy for sensitive and non-invasive imaging and phototherapy of ocular tumors.

reference

Luoyuan Li, et al. Microenvironment-Triggered Degradable Hydrogel for Imaging Diagnosis and Combined Treatment of Intraocular Choroidal Melanoma. ACS Nano, 2020.

2) The effects of different treatment conditions on in vivo and in vitro nIR-II imaging detection and anti-tumor activity of ocular choroidal melanoma-1 cells and tumor-bearing mice were systematically compared.

DOI: 10.1021 / acsnano. 0 c06000

https://doi.org/10.1021/acsnano.0c06000

Source: Theory of Oddities

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