已传文件：photo/1769223242.png
Abstract:
Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration, subchondral bone remodeling, and chronic inflammation, and current treatments struggle to address its underlying mechanisms. In this study, a CaCO₃-coated ZIF-8 composite molybdenum nanozyme (CaCO₃@ZIF-8@Mo-TA) was constructed, and this nanomaterial was characterized using various techniques. Its therapeutic potential was then explored in an osteoarthritis rat model. The study found that this nanozyme can exert antioxidant and anti-inflammatory effects by regulating key signaling pathways, providing a new potential strategy for the treatment of osteoarthritis.
Research Background
Osteoarthritis, as a common degenerative joint disease, is characterized by cartilage degradation, subchondral bone remodeling, and persistent chronic inflammation. Current treatment approaches mostly focus on symptom relief and do not address the fundamental mechanisms underlying disease development, highlighting the urgent need for new therapies that can specifically target and modulate these pathological processes.
Original Source:
Authors: Bing Tan, Yuhao Zheng, Jie Hao, Qiyuan Yang, Xiao Luo, Qin Li, Xiaoyan Zhang, Jianyuan Ouyang, Jisheng Wang, Zhenming Hu
Pub Date: 2025-01-01
DOI: 10.1007/s42114-025-01219-y
Journal: Advanced Composites and Hybrid Materials
