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Abstract:
This article is a review that systematically examines the structure and function of bone sialoprotein (BSP), focusing on its physiological regulatory role as the main non-collagen protein in the extracellular matrix of bone cells during bone remodeling, as well as its association with abnormal expression and tumor progression, and bone metastasis. It deeply analyzes the molecular mechanisms by which it mediates related biological processes and clarifies the multi-functional regulatory status of BSP.
01 Research Background
BSP is a major non-collagen protein in the extracellular matrix of bone cells, playing a core role in the regulation of bone formation and bone resorption, and is widely present in tissues such as bone, dentin, and cartilage. The abnormal expression of BSP in primary tumor tissues and serum of patients with metastatic cancer suggests that it may be involved in tumor biological processes, providing a research background for further exploration of its cross-regulatory role.
02 Main Content
This article conducts a comprehensive review on the structure and function of BSP, covering two core functions: one is the physiological regulation of angiogenesis, bone formation, and osteoclast differentiation and activity; the other is the pathological involvement in tumor cell proliferation, survival, complement evasion, adhesion, migration, invasion, and bone metastasis. It also analyzes its mechanism of action, including RGD-integrin binding, the integrin/BSP/matrix metalloproteinase axis, integrin-independent signaling pathways, epithelial-mesenchymal transition, and potential post-translational modifications.
03 Research Design
Based on existing scientific evidence, a review-based research method is adopted to systematically integrate relevant research results of BSP in the physiological regulation of bone and the pathological progression of tumors, focusing on its structural characteristics, multi-functional regulatory role, and molecular mechanisms, and constructing a network of their interrelationships.
04 Results
It is clear that BSP is a key regulatory medium mediating tumor pathological physiology, bone metastasis development, and related bone remodeling. It achieves cross-regulation of bone physiological processes and tumor progression through multiple molecular mechanisms. The related research evidence further solidifies the multi-functional regulatory status of BSP.
05 Extension of Thoughts
This provides a systematic theoretical framework for further in-depth exploration of the role mechanism of BSP in the cross-field of bone physiology pathology and tumor, and provides a clear direction for basic research around BSP (such as regulatory network analysis, functional verification, etc.).
Original Source:
① Journal: Bone Research
② Publication Date: 2026-01-01
③ DOI: 10.1038/s41413-025-00490-5 ④ Authors: Valentina Kottmann, Philipp Drees, Erol Gercek, Ulrike Ritz
