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Recently, a research team led by Qi Yiying, Xu Jianbin from the Second Affiliated Hospital of Zhejiang University School of Medicine and Wang Wei from Zhejiang University successfully developed a sonoreponsive hydrogel (MIL-101(Fe)@ZnO@MM + PFO + Gel) that mimics the membrane of macrophages for the treatment of osteomyelitis induced by methicillin-resistant Staphylococcus aureus (MRSA). This study ingeniously integrates three functions: sonodynamic catalysis, oxygen delivery, and immunomodulation, providing a new comprehensive treatment strategy for refractory osteomyelitis. The work was titled "Sonocatalytic Multifunctional Hydrogel In-situ Remodels the Infectious Microenvironment for Eradicating Refractory Osteomyelitis" and was published in the Journal of Controlled Release.
Osteomyelitis, especially chronic osteomyelitis caused by drug-resistant bacteria, has always been a "hard nut to crack" in clinical treatment. When pathogenic bacteria such as MRSA infect bone tissue, they form a dense biological membrane. This physical barrier composed of polysaccharides, proteins, and DNA hinders the penetration of antibiotics, causing the bacteria to enter a dormant state and developing extremely strong resistance. Moreover, the continuous infection triggers uncontrollable inflammatory responses: a large amount of pro-inflammatory cytokines (such as TNF-α, IL-1β) activate osteoclasts, leading to bone dissolution and destruction; at the same time, they inhibit the activity of osteoblasts, causing bone repair to stagnate. Simultaneously, the impaired local blood supply leads to an oxygen-deprived environment, further exacerbating the vicious cycle of inflammation and bone destruction.
Original link：https://www.sciencedirect.com/science/article/pii/S0168365926000878?via%3Dihub=
