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Nell-1 promotes osteogenic differentiation and mineralization of hPDLSCs and upregulates CYFIP1, Runx2, and CGRP-related signaling; disrupting CYFIP1 affects the osteogenic effects mediated by Nell-1. The CPC-aMF scaffold has a hierarchically micro-fibrous structure, suitable mechanical properties, and degradation behavior, which can protect the seed cells and achieve dual-phase release of Nell-1. In vivo, scaffolds containing hPDLSCs and Nell-1 promote new bone formation, collagen deposition, and defect repair, while also enhancing angiogenesis and nerve ingrowth, with increased markers like CGRP, β3-tubulin, and CD31. Mechanistically, Nell-1 links nerves and osteogenesis through the CYFIP1-MAPK/ERK-Runx2 axis.
Original Source:
Smart Molecules
Pub Date: 2026-07-15
DOI: 10.1002/smo2.70078
Minjia Zhu, Xinyi Li, Jingyi Li, Kan Yu, Zixiang Dai, Le Xiao, Qinrou Zhang,
Zihan Jia, Qingchen Qiao, Zeqing Zhao, Ke Zhang, Yuxing Bai
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